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CHARACTERIZATION AND SENSITIVITY PATTERN OF BACTERIAL PATHOGENS ISOLATED FROM PNEUMONIA PATIENTS UNDER 5 YEARS OF AGE: A HOSPITAL-BASED STUDY (Pages : 59 - 64)

S. DAS, M. S. KHAN, P. K. NEOGI, N. AKHTAR AND M. J. ISLAM

A surveillance study on pneumonia was undertaken at Chittagong Maa-Shishu-O-General Hospital, Bangladesh during February 2007 to June 2007. It was conducted in order to isolate, identify and determine the sensitivity pattern of this disease causing agents from blood and cerebrospinal fluid (CSF) of hospitalized children less than 5 years of age to document the burden of these agents in Chittagong; Bangladesh. A no. of tests including cytological, biochemical, cultural and antimicrobial susceptibility test by Kirby-Bauer disc diffusion method was performed for their confirmative identification and for concerning their sensitivity pattern. Out of 547 blood samples, 52 (9.51%) yielded bacterial growth of which K. pneumoniae, 29 (55.77%) was the most frequent offender. It was followed by Serratia spp., 07 (13.46%); Acinetobacter spp., 5 (9.62%); Staphylococcus aureus, 4 (7.69%) etc. Only 01 (1.92%) Haemophilus influenzae was isolated from blood. From 53 CSF samples, number of bacterial isolates were 3 (5.66%) of which Streptococcus pneumoniae were 02 (66.67%) and the rest was pseudomonas aeruginosa (33.33%). Studies on age-dependent variation of bacterial isolates revealed that neonates (13.56%) are particularly vulnerable to infections because of weak immune barrier. Imipenem was found to be more active against Klebsiella, Serratia, and Proteus spp. than other antibiotics. Again Acinetobacter spp. was found to be more sensitive against imipenem and ciprofloxacin. Other Enterobacteriaceae family such as E. coli and Pseudomonas spp. offered sensitivity towards extended spectrum ciprofloxacin, imipenem as well as co-trimoxazole. The fluorinated quinolones, in particular ciprofloxacin and ?-lactams, in particular ceftriaxone are still active against Streptococcus Pneumoniae. Pneumococcal isolation rate was very low both from blood and CSF. This study will provide local information on the common serotypes so that the future formulation of pneumococcal and other vaccines basDownload


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