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ANTIMICROBIAL SUSCEPTIBILITY OF Salmonella SEROVARS ISOLATED FROM BLOOD (Pages : 22 - 27)

M. J. ISLAM, K. K. DAS, N. SHARMIN, M. N. HASAN AND A. K. AZAD

The prospective study was conducted in LabAid Hospital, Dhaka, Bangladesh on patient’s attending for the treatment of suspected bacterium during January 2008 to May 2008. For optimal patients care and saving hospital cost, precise information on antibiotic susceptibility pattern should be available to the clinician. With the aim of giving a message to the clinicians about the susceptibility pattern of Salmonella typhi and Salmonella paratyphi A, blood culture was done for 50 suspected cases of enteric fever and 30 strains of salmonella typhi and 16 strains of salmonella paratyphi A were isolated and identified by specific antisera and with standard biochemical tests. Antimicrobials susceptibilities were determined by Kirby-Bauer disc diffusion method using 16 different routinely used antibiotics. Antibiotic susceptibility test demonstrated that 50% isolates of S. typhi and 83.33% isolates of S. paratyphi A were multidrug resistant. All of the isolates of S. typhi were sensitive (100%) to Aztreonam Amikacin and Gentamycin and all of the isolates of S. paratyphi A were sensitive (100%) to Aztreonam, Amikacin, Cefaclor, Cefixime, Ceftazidime, Ceftriaxone, Gentamycin, Mecillinam. All of the isolates of Salmonella typhi and Salmonella paratyphi A were resistant to Nalidixic acid (100%). In addition isolates of S. paratyphi A were also resistant to Azithromycin, Netilmicin. Decreased susceptibility of S. typhi and S. paratyphi A was observed in case of ciprofloxacin 73.33% and 70% respectively. Our study concludes that appropriate data of antimicrobial susceptibility should available to all of the clinicians for prescribing an antibiotics, Aztreonam Amikacin ,Gentamycin and Aztreonam, Amikacin, Cefaclor, Cefixime, Ceftazidime, Ceftriaxone, Gentamycin, Mecillinam should be the choice of antibiotics for the treatment of S. typhi and S. paratyphi A infections respectively.Download


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